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Updated: Jul 13, 2026

Detection of Neu1 Sialidase Activity in Regulating TOLL-like Receptor Activation
09:04

Detection of Neu1 Sialidase Activity in Regulating TOLL-like Receptor Activation

Published on: September 7, 2010

Tリンパ球活性化における重要なシグナル伝達酵素としてのカルシヌーリンの特定

N A Clipstone1, G R Crabtree

  • 1Beckman Center for Molecular and Genetic Medicine, Howard Hughes Medical Institute, Stanford University School of Medicine, California 94305.

Nature
|June 25, 1992
PubMed
まとめ

T細胞におけるカルシヌーリンの過剰発現により,サイクロスポリンA (CsA) やFK506.6のような免疫抑制薬に耐性が生じます. この発見は,カルシネウリン尿を明らかにしています.

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