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Updated: Jul 17, 2026

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors
05:46

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors

Published on: April 9, 2014

結晶構造は3.5 Aで,HIV-1逆転写酵素の解像度が阻害剤と複合している

L A Kohlstaedt1, J Wang, J M Friedman

  • 1Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06511.

Science (New York, N.Y.)
|June 26, 1992
PubMed
まとめ

この研究は,ネビラピンと複合したHIV-1逆転写酵素の非対称な構造を明らかにしています. 薬剤結合部位はポリメラーゼ活性部位に近いが,ポリメラーゼ活性部位とは分離しており,エイズ治療に関する洞察を提供している.

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