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タンパク質チロシンフォスファタゼの過剰発現によるpp60c-srcの細胞変容と活性化

X M Zheng1, Y Wang, C J Pallen

  • 1Cell Regulation Laboratory, National University of Singapore.

Nature
|September 24, 1992
PubMed
まとめ

タンパク質チロシンフォスファタゼアルファ (PTPα) の過剰発現は,持続的にpp60c-srcキナーゼを活性化させ,細胞変異と腫瘍発生につながります. この活性化には,負の調節部位であるTyr527.7の脱酸化が伴う.

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