リポプロテイン (a) は,血液透析患者の心血管疾患の独立リスク因子である
M D Cressman1, R J Heyka, E P Paganini
1Department of Heart and Hypertension Research, Cleveland Clinic Foundation, OH 44195-5069.
Circulation
|August 1, 1992
まとめ
脂質タンパク質の上昇 (Lp) は,血液透析患者における動脈硬化性心血管疾患の独立リスク因子である. この研究は,この高リスク集団における臨床イベントの有意な予測因子としてのLp (a) を確認しています.
科学分野:
- 心血管医学 心血管医学
- ネフロロジーはネフロロジーを用います.
- 臨床化学 臨床化学について
背景:
- 血清リポプロテイン (Lp) は,既知の動脈硬化リスク因子である.
- Lp (a) レベルは,血液透析患者で上昇しています.
- Lp(a) と血液透析患者の臨床イベントとの関連は,以前は確立されていなかった.
研究 の 目的:
- Lp (a) レベルと動脈硬化症に起因する臨床イベントのリスクとの関連性を決定する.
- 慢性血液透析患者における独立したリスク因子としてのLp (a) を調査する.
主な方法:
- 129人の出院血液透析患者が参加した前向きな研究.
- 放射性免疫測定法で,ベースラインのLp (a) レベルを測定する.
- 推定された動脈硬化病因の臨床的イベントを評価するために,48ヶ月の追跡調査.
主要な成果:
- 血液透析を受けた患者は,対照群と比較して,平均Lp (a) 値が有意に高かった.
- ベースラインのLp (a) 濃度は,フォローアップ中の臨床イベントの有意な予測因子でした.
- Lp (a) と以前の臨床イベントは,将来のリスクに独立して寄与する唯一の要因でした.
結論:
- 血清Lp (a) は,動脈硬化性心血管疾患の独立リスク因子である.
- この発見は,末期腎疾患のために慢性血液透析を受けている患者にとって重要である.
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