ポリペプチドの抗原性:ガンマアミノ酸の共ポリマーに対する免疫学的反応の欠如

P H MAURER, R LOWY, C KIERNEY

Science (New York, N.Y.)

|March 15, 1963

まとめ

新生児のウサギは,単発注射後に合成アミノ酸コポリマーに対する免疫的耐性を発達させた. この耐性は,より多くの抗原で延長されても,補助剤の混合物中のポリマーを使用して逆転することができます.

科学分野:

免疫学免疫学とは
ポリマーサイエンスの科学
バイオケミストリーバイオケミストリー

背景:

免疫学的な耐性は,自己免疫疾患の予防に不可欠です.
合成ポリマーは,耐性誘導を研究するためのモデルシステムを提供します.

研究の目的:

合成アミノ酸コポリマーを用いて免疫的耐性の誘導と調節を調査する.
誘導された耐性を拡張または破る方法を探求する.

主な方法:

新生ウサギの免疫的耐性の誘導は,3つの異なる合成ランダムコポリマーの単一の注射によるものです.
耐性状態の持続時間を評価するために,追加の抗原を投与する.
耐性を打破しようとする補助剤混合物におけるポリマー抗原の使用.

主要な成果:

合成アミノ酸コポリマーの一回注射で,新生児のウサギに免疫的耐性を成功裏に誘導しました.
耐性状態は,その後の静脈注射抗原投与によって延長された.
補助剤の混合物へのポリマーの繰り返し注射は,確立された耐性を破るのに効果的でした.

結論:

合成アミノ酸コポリマーは,免疫的耐性を効果的に誘発することができます.
耐性の期間は,抗原への曝露によって変化します.
補助剤ベースの免疫療法は,これらの合成抗原に対する既定の耐性を克服することができます.

キーワード:

アンチゲン (Antigens) とはグルタミン酸は,

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