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Updated: Jul 8, 2026

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Murine Echocardiography of Left Atrium, Aorta, and Pulmonary Artery
Published on: February 20, 2017
高齢者の大動脈狭窄における左心房機能の性別による差異
J D Carroll1, E P Carroll, T Feldman
1Department of Internal Medicine, University of Chicago, IL 60637.
Circulation
|October 1, 1992
まとめ
性別は,左心室が高齢者の重度の大動脈狭窄にどのように適応するかに影響する. 女性は排泄能力が保たれ,男性は機能障害と高心室質量の兆候を示しています.
科学分野:
- 心臓病学 心臓病学
- 心血管生理学 心血管の生理学
- ゲリアトリクス ゲリアトリクス
背景:
- 大動脈狭窄 (AS) の圧力過負荷への左心室 (LV) の適応は,補償性高縮から心不全まで様々です.
- ASにおけるLV適応を決定する要因は不明である.
研究 の 目的:
- 60歳以上の成人の重症弁動脈狭窄へのLV適応における性別の役割を調査する.
- 重度のASを持つ男性と女性のLV機能と構造を比較する.
主な方法:
- 重度のASを持つ34人の女性と29人の男性からの血液動力学およびエコーカルディオグラフィのデータを遡及的に分析した.
- 有意な冠動脈疾患を有する患者の除外.
- 乳房外流阻害の重度,乳房外流機能のパラメータ,腔室の大きさ,圧力,心臓の出力量を性別で比較する.
主要な成果:
- 類似のLV流出阻害にもかかわらず,女性は男性と比較して,より大きな分数縮小,より小さな末端シストリック室のサイズ,およびより高い圧力生成を示しました.
- 男性は心臓指数が低く,肺動脈の圧力が高く,排泄期間が短かった.
- 女性 (41%) よりも男性 (14%),小型で厚いLV室と低い壁のストレスに関連した超正常なLV射出性能がより一般的でした.
- 異常なLVエジェクション性能は,女性 (18%) よりも男性 (64%) により一般的であったが,これは,室の大きさの増加と高い壁のストレスに関連していた.
- 男性のLV質量は女性よりも高かった.
結論:
- 性別は,重度の弁動脈大動脈狭窄症の成人のLV適応の重要な決定因子です.
- 重度のASを持つ高齢女性は,高齢男性と比較して,LVの機能的,構造的な特徴が異なっています.
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