マグネシウム投与と心臓外科手術後の不律律症. プラセボ対照,ダブルブラインド,ランダム化試験でした
M R England1, G Gordon, M Salem
1Department of Anesthesia, New England Medical Center Hospital, Tufts University School of Medicine, Boston, Mass.
JAMA
|November 4, 1992
まとめ
マグネシウムの投与は,心房不律症を効果的に軽減し,心臓手術後の心臓指数を改善しました. この研究は,手術後の合併症の管理におけるマグネシウムの利点,特に低マグネシウム血症の患者の効果を強調しています.
科学分野:
- 心血管外科手術についてです.
- アネステシオロジー アネステシオロジー
- クリティカルケア・メディシン
背景:
- ハイポマグネセミアは,心臓外科手術患者の間で一般的です.
- 術後の低磁石血症は,罹病率の増加と関連しています.
研究 の 目的:
- 術後の罹病率と死亡率を低減するマグネシウム投与の有効性を評価する.
- 手術後のマグネシウムの心臓機能と心律乱に対する影響を評価する.
主な方法:
- ランダム化,ダブルブラインド,プラセボ対照試験で,心臓外科手術を受けた患者100人が参加しました.
- 患者は手術中にマグネシウム塩化物注入またはプラセボを受けた.
- ディスリズム障害と心臓指数を含む術後のアウトカムをモニターした.
主要な成果:
- マグネシウムで治療を受けた患者は,手術後の心室不律症が有意に少なくなった (16% vs 34%).
- ノルマグネセミアの患者は,ヒポマグネセミアの患者と比較して,より少ない数の超心室不律を経験しました.
- マグネシウム投与は,術後の心臓指数 (2.8対2.5L/分/m2) を高めた.
結論:
- マグネシウムの投与は心室不律を軽減し,早期の術後の心臓指数を改善します.
- 術後の低磁血症は,心室不律症の増加と,機械呼吸器の延長と関連しています.
- マグネシウムは,心臓外科手術患者の低マグネセミアおよび関連する合併症の管理に有益です.
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