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Updated: Jun 22, 2026

Spatio-Temporal Manipulation of Small GTPase Activity at Subcellular Level and on Timescale of Seconds in Living Cells
10:27

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マウスにおけるRb変異の効果

T Jacks1, A Fazeli, E M Schmitt

  • 1Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge 02142.

Nature
|September 24, 1992
PubMed
まとめ

網膜芽細胞腫遺伝子 (Rb) は,がんの予防に不可欠です. ネズミの1つのRb遺伝子コピーを破壊すると,網膜芽細胞腫は発生しませんが,細胞死と欠陥のある血液形成により,下垂体腫瘍と胚死亡を引き起こします.

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