まとめ
ヒトアデノウイルス12型は,新生マウスの無差別悪性腫瘍を誘発し,特にC(3) H(f) / G(8) 株を誘発した. 腫瘍の発達が観察されましたが,ハムスターと比較して低いペースで観察されました.
科学分野:
- 腫瘍学 腫瘍学
- ウイルス学 ウイルス学 ウイルス学
- 遺伝学 遺伝学とは
背景:
- ヒトアデノウイルス12型 (HAdV-12) は,ハムスターの腫瘍を誘発することが知られている.
- 異なるマウス株におけるHAdV-12の腫瘍発生の可能性は,十分に特徴づけられていない.
研究 の 目的:
- 異なる遺伝的背景を持つ新生マウスのヒトアデノウイルス12型の腫瘍発生可能性を調査する.
- ネズミの腫瘍誘導とハムスターの腫瘍誘導を比較する.
主な方法:
- 新生マウスのC(3) H(f) /G(8),DBA(f),A(f) 株にヒトアデノウイルス12型を注射した.
- 腫瘍の発達をモニタリングし,誘発された腫瘍を総体および組織学的に分析した.
主要な成果:
- 不分化悪性腫瘍は,C(3) H(f) /G(8) 株のマウスの注射部位で誘発された.
- マウスのDBA (f) またはA (f) 株では腫瘍は観察されなかった.
- 誘発された腫瘍は,ヒト組織学的にハムスターに見られるものに似ているが,マウスではより低い割合で発生した.
結論:
- マウスのC(3) H(f) / G(8) 株はアデノウイルス12型誘発腫瘍形成に敏感である.
- マウス株の遺伝学は,アデノウイルス誘発の腫瘍形成において重要な役割を果たします.
- ハムスターが誘発する腫瘍に類似しているが,HAdV-12の腫瘍性性は,感受性の高いマウス株ではより効率的ではない.
関連する概念動画
Mechanisms of Retrovirus-induced Cancers
Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
Rous Sarcoma Virus (RSV) and Cancer
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
Mechanisms of Retrovirus-induced Cancers
Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
Rous Sarcoma Virus (RSV) and Cancer
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
Cytomegalovirus Disease
Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
Hepatitis
Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...


