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Neurulation

Neurulation

Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the anterior...

Cell Migration

Cell Migration

Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.

Cell Migration

Cell Migration

Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.

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Updated: Jun 20, 2026

Migratory Behavior of Cells Generated in Ganglionic Eminence Cultures

Migratory Behavior of Cells Generated in Ganglionic Eminence Cultures

Published on: April 21, 2011

発達中の脳皮質における様々な移動経路.

N A O'Rourke¹, M E Dailey, S J Smith

¹Department of Biological Sciences, Stanford University, CA 94305.

Science (New York, N.Y.)

|October 9, 1992

まとめ

この要約は機械生成です。

哺乳類の脳皮質発達の過程で,若いニューロンは外へ移動する. いくつかのニューロンは,状繊維に沿って放射的に移動し,他のニューロンは直角的に移動し,潜在的にニューロンの分散を助けます.

さらに関連する動画

Ex Utero Electroporation and Organotypic Slice Cultures of Embryonic Mouse Brains for Live-Imaging of Migrating GABAergic Interneurons

Ex Utero Electroporation and Organotypic Slice Cultures of Embryonic Mouse Brains for Live-Imaging of Migrating GABAergic Interneurons

Published on: April 20, 2018

Time-Lapse Imaging of Migrating Neurons and Glial Progenitors in Embryonic Mouse Brain Slices

Time-Lapse Imaging of Migrating Neurons and Glial Progenitors in Embryonic Mouse Brain Slices

Published on: March 8, 2024

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Last Updated: Jun 20, 2026

Migratory Behavior of Cells Generated in Ganglionic Eminence Cultures

Migratory Behavior of Cells Generated in Ganglionic Eminence Cultures

Published on: April 21, 2011

Ex Utero Electroporation and Organotypic Slice Cultures of Embryonic Mouse Brains for Live-Imaging of Migrating GABAergic Interneurons

Ex Utero Electroporation and Organotypic Slice Cultures of Embryonic Mouse Brains for Live-Imaging of Migrating GABAergic Interneurons

Published on: April 20, 2018

Time-Lapse Imaging of Migrating Neurons and Glial Progenitors in Embryonic Mouse Brain Slices

Time-Lapse Imaging of Migrating Neurons and Glial Progenitors in Embryonic Mouse Brain Slices

Published on: March 8, 2024

科学分野:

神経科学は神経科学である.
発達生物学発達生物学とは
細胞生物学細胞生物学

背景:

哺乳類の脳皮質の発達中に,新しく形成されたニューロンは,心室領域から皮質板に移動し,成人皮質を確立します.
ニューロンの移動は,脳の複雑な神経回路を形成するための基本的なプロセスです.

研究の目的:

哺乳類の発達中の脳皮質の生きたスライスに移動するニューロンのダイナミックな行動を直接観察する.
早期発達中の皮質ニューロンの移動経路と行動を調べる.

主な方法:

タイムラップコンフォカル顕微鏡を用いて,細胞動態をリアルタイムで視覚化しました.
哺乳類の発達中の脳皮質の生体組織の断片を観察のために使用した.

主要な成果:

移動するニューロンのほとんどは,放射性経路をたどり,放射性状繊維に沿った移動に合わせます.
ニューロンのサブセットは,半径経路から逸脱して,中間領域内で直角移動を示した.
観察された正交移動は,クローン的に関連したニューロンの接点分散のメカニズムを示唆する.

結論:

皮質ニューロンは,放射性膠質繊維に沿って移動しますが,異なる集団は,正方形にも移動します.
オートゴーナル移動は,皮質ニューロンの接点分散と空間的組織に重要な役割を果たす可能性があります.
これらの移動パターンを理解することは,皮質の発達と潜在的な発達障害を理解するために不可欠です.