非対称性隔膜縮および心筋線維の障害. 正常な心臓,発達中の心臓,心不全の心臓の特徴
Circulation
|August 1, 1977
まとめ
非対称性隔膜縮症 (ASH) と心筋繊維の障害は,イディオパシー性高縮性下大動脈狭窄症 (IHSS) に特異的ではない. これらの発見は,正常な発達中の心臓および特定の先天性疾患で発生し,IHSSの決定的なマーカーではないことを示しています.
科学分野:
- 心血管病理学 心血管病理学
- 発達生物学 発達生物学とは
- 心臓の形質について
背景:
- 非対称性隔膜縮症 (ASH) とイディオパシー性縮性下大動脈狭窄症 (IHSS) の心筋繊維障害の診断特異性は不明である.
- 様々な心疾患におけるこれらの特徴の起源と有病率を理解することは,正確な診断に不可欠です.
研究 の 目的:
- 多種多様な心臓サンプルでASHと心筋繊維の混乱の発生と重要性を調査する.
- これらの形態学的発見がIHSSの病名性であるかどうかを判断する.
主な方法:
- 発達段階 (胚から成人まで) にわたる正常な個体と,先天性または既得性心疾患を有する個体の215本の心臓の組織学的な検査.
- septal morphologyと正常心筋線維の配置の比較分析. 正常心と病的な心との比較.
主要な成果:
- 不均衡な隔膜厚み (ASH) は,すべての胚およびいくつかの異常な心臓,特に右心室縮 (RVH) を有する胚で観察されました.
- 心筋線維の障害は,特定の交差点にあるすべての心臓に存在し,半月膜縮症やフォロの四重症などの状態で広範な障害が認められた.
- ASHと有意な繊維の混乱は,IHSS以外の条件で発見されました.
結論:
- 非対称性隔膜縮症 (ASH) は,正常な心臓発達の特徴であり,右心室縮症 (RVH) の心異常に存在することがあります.
- 顕著な心筋繊維の障害は,異常な静脈収縮に関連した先天性心臓病変で発生することがあります.
- ASHも心筋線維の障害も,個別に,または組み合わせて,イディオパシー性多動性下大動脈狭窄症 (IHSS) の病理学的な特徴ではありません.
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