まとめ
感受性の高いドナーのリンパ球を用いて,花粉アレルギーの被動的移転が達成されました. これは,遅延過敏反応の細胞媒介免疫伝達を示しています.
科学分野:
- 免疫学 免疫学とは
- 細胞免疫学 細胞免疫学
背景:
- 遅延過敏症は,重要な免疫反応である.
- 花粉の抗原はアレルギー反応を引き起こす可能性があります.
研究 の 目的:
- 花粉の抗原に対する遅延した皮膚過敏性の被動的移転を証明するために.
- この転移におけるリンパ球の役割を調査する.
主な方法:
- リンパ球製剤は,敏感化されたドナーの周辺血液から分離した.
- 粒細胞と血小板は,シリコンコーティングされたガラスビーズコラムを使用して除去されました.
- 薬剤は反応しない被験者に注射された.
主要な成果:
- 遅延性皮膚過敏症の受動的転移が8回成功しました.
- 移植は花粉抗原に特異的であった.
結論:
- リンパ球は,遅延過敏症の受動的移転を媒介する.
- 細胞の免疫反応は,個体から個人に転移することがあります.
関連する概念動画
Cell-mediated Immune Responses
Overview
Special Features of Adaptive Immunity
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
Cells of the Adaptive Immune Response
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
Hypersensitivity Reactions: Delayed Hypersensitivity Reactions
Delayed-Type Hypersensitivity (DTH), or Type IV hypersensitivity, is a cell-mediated immune response. It occurs when T cells, rather than antibodies, mediate a reaction to specific antigens. It is characterized by a delayed onset (1-2 days) and involves the recruitment of macrophages to the inflammation site.The initiation of a DTH response begins with the sensitization of T cells. During this phase, which lasts at least 1-2 weeks, antigen-specific T cells are activated, clonally expanded, and...


