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関連する概念動画

Lethal Alleles02:41

Lethal Alleles

Agouti: A Lethal Allele
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

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関連する実験動画

Updated: Jun 30, 2026

Chronic Salmonella Infected Mouse Model
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Chronic Salmonella Infected Mouse Model

Published on: June 1, 2010

選択的なラット 有毒性有毒性

A P ROSZKOWSKI, G I POOS, R J MOHRBACHER

    Science (New York, N.Y.)
    |April 24, 1964
    PubMed
    まとめ

    珍しいフルヴェンのマレイミド添加物は,ネズミに高い毒性を示しています. しかし,一般的なペットや商業的に有用な動物は,より高い用量でも有意な毒性効果を示さない.

    科学分野:

    • 毒理学 毒理学 毒理学
    • 有機化学 オーガニック・ケミストリー

    背景:

    • フルベンは有機化合物のクラスである.
    • マレイミド添加物は生物学的活性を示すことができる.

    研究 の 目的:

    • 異常なフルヴェネの特定のマレイミドアドクトの毒性を評価するために.
    • 異なる動物種間の毒性を比較する.

    主な方法:

    • マレイミドアダクトの経口および親体投与は,ラットに投与された.
    • 一般的な家庭のペット,商業的に有用な哺乳類,鳥類に高用量投与.

    主要な成果:

    • マレイミドアダクトは,ネズミに非常に有毒であることが判明しました.
    • ペット,哺乳類,鳥類において,ネズミの致死量より200倍も高い用量で,有意な有毒性または生物学的変化は観察されなかった.

    結論:

    • 珍しいフルヴェンのマレイミド添加物は,種特有の毒性を表しています.
    • ネズミは非常に感受性があり,一般的な家庭用および商業用動物は顕著な耐性を示しています.
    キーワード:
    カットル (CATTLE) とは化学,分析的化学についてDOGS DOGS 犬について実験実験室での研究ギニアブタはギニアブタです."馬"とは,馬のことです.類人猿 (monkeys) とは 類人猿 (monkeys) とは 類人猿 (apes) とは鶏肉 鶏肉を飼っている.ウサギ (うさぎ) はウサギである.ラット (RATS) とはRODENTICIDES ロドンティシデス羊 羊は羊を飼っている.種は特異性を有する.毒理学レポート

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