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生まれながらの心臓手術後の呼吸不全のための高周波ジェット換気
K C Kocis1, J N Meliones, M K Dekeon
1Department of Pediatrics, C.S. Mott Children's Hospital, University of Michigan, Ann Arbor 48109-0204.
Circulation
|November 1, 1992
まとめ
高周波ジェット換気 (HFJV) は,先天性心臓手術後の小児患者の呼吸不全 (RF) を効果的に治療し,体外膜酸素化 (ECMO) に有効な代替品として機能します. この方法により,換気とガス交換が改善され,患者の89%がRFの解消を示した.
科学分野:
- 小児重症病棟医療 幼児重症病棟医療
- 心胸外科手術についてです.
- 呼吸器生理学 呼吸器生理学について
背景:
- 呼吸器不全 (RF) は,先天性心臓手術後の重大な合併症である.
- 身体外膜酸素化 (ECMO) は,持続的なRFに対する救済療法です.
- 従来の機械換気 (CMV) は,重度のRFの場合では不十分かもしれません.
研究 の 目的:
- RFの先天性心臓外科手術後のECMOの代替手段として,高周波ジェット換気 (HFJV) を評価する.
- 換気とガス交換の改善におけるHFJVの有効性を評価する.
- HFJVパラメータとCMVを比較する.
主な方法:
- ECMOを必要とする先天性心疾患とRFの9人の小児患者のコホートは,HFJVで治療されました.
- HFJVは手術後2週間以内に開始されました.
- 呼吸器のパラメータと動脈の血液ガスは,HFJV前およびその間にモニタリングされました.
主要な成果:
- HFJVは89%の患者 (8人中9人) でRFを解消しました.
- HFJVの1時間後に,動脈のpHが有意に上昇 (p <0.05) し,PaCO2は有意に減少 (p <0.05) した.
- 吸入酸素分数 (FIO2) は,CMVと比較して,平均気道圧 (PAW) または他の血液動力学的パラメータの変化なしに,有意に減少しました (p <0.05).
結論:
- HFJVは,先天性心臓手術後の小児患者の呼吸不全の効果的な治療法です.
- HFJVは,生命を救う可能性のあるECMOの代替案を提供します.
- この集団におけるHFJVの使用を最適化するために,さらなる研究が必要である.
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