人間の胃エピプロイと左側の内部乳腺動脈の間の血管運動制御の違い
H Buikema1, J G Grandjean, S van den Broek
1Department of Pharamcology/Clinical Pharmacology, University Hospital Groningen, The Netherlands.
Circulation
|November 1, 1992
まとめ
ガストロエピプロイク動脈と左側の内側乳腺動脈は,いくつかの血管活性物質に対して同様の反応を示しますが,ガストロエピプロイク動脈はブラジキニンに対してより大きなリラックスを示し,冠動脈バイパス移植の内皮機能の潜在的な違いを示唆しています.
科学分野:
- 血管外科 血管外科
- 心血管科学の研究について
- 内皮機能の機能について
背景:
- 内部乳腺動脈移植は,サフェノス静脈移植と比較して,長期的に優れた透かし性を提供します.
- 動脈と静脈の血管の間の内皮機能の違いが関与しています.
- ガストロエピプロイク動脈は,内部乳腺動脈との類似性のために,冠動脈バイパス移植においてますます使用されています.
研究 の 目的:
- ガストロエピプロイク動脈と左側の内部乳腺動脈移植の内皮反応を比較するために.
- 様々な血管活性物質に対する彼らの反応を調査する.
主な方法:
- ガストロエピプロイック動脈と左内乳腺動脈は,冠動脈バイパス手術を受けた患者から採取した.
- 血管のリングは,臓器浴実験の対象とされました.
- メタホリン,ナトリウム窒素,ブラジキニンに対するリラックス反応を測定した.
主要な成果:
- 両動脈ともメタホリンとナトリウム窒素酸塩に対する同様のリラックス反応を示した.
- ブラディキニンは,胃エピプロイ性動脈のリングの有意な緩和を誘発したが,左側の内側乳腺動脈のリングではそうではなかった.
- 年齢と最大メタコリン誘発のリラクゼーションの間で,左側の内部乳腺動脈のリングで負の相関が観察されました.
結論:
- メタコリンとナトリウム窒素に対する同様の反応は,両動脈におけるL-アルギニンの経路活性が類似することを示唆しています.
- ブラジキニン反応の差異は,胃動脈におけるプロスタグランディン代謝の違いを示唆する可能性があります.
- ガストロエピプロイク動脈とは異なり,左側の内部乳腺動脈の年齢依存の緩和が認められた.
関連する概念動画
Anatomy of the Circulatory System
The human circulatory system consists of blood, blood vessels that carry blood away from the heart, around the body, and back to the heart, and the heart itself, which acts as a central pump. The systemic circuit supplies blood to the whole body, the coronary circuit supplies blood to the heart, and the pulmonary circuit supplies blood flow between the heart and lungs.
Blood Flow
Blood is pumped by the heart into the aorta, the largest artery in the body, and then into increasingly smaller arteries, arterioles, and capillaries. The velocity of blood flow decreases with increased cross-sectional blood vessel area. As blood returns to the heart through venules and veins, its velocity increases. The movement of blood is encouraged by smooth muscle in the vessel walls, the movement of skeletal muscle surrounding the vessels, and one-way valves that prevent backflow.
Structure of Blood Vessels
Blood is circulated throughout the human body through a network of blood vessels called the circulatory system. This system includes arteries that transport blood from the heart to various body parts. These arterial pathways divide into smaller vessels until they reach the arterioles, which further split into capillaries. It is within these minuscule capillaries that the exchange of nutrients and waste products takes place. After this exchange, the blood is collected by venules, which fuse to...
Arteries and Arterioles
Arteries, the vasculature responsible for transporting blood from the heart, possess robust walls capable of enduring the elevated pressures exerted by the heartbeat. Arteries near the heart are especially thick-walled and enriched with elastic fibers across their three tunics, classifying them as elastic or conducting arteries. These arteries, usually with a diameter exceeding 10 mm, are characterized by their ability to dilate in response to the blood pumped from the heart's ventricles and...
Abdominal Aorta
Once the aorta traverses the diaphragmatic plane at the aortic hiatus, it is known as the abdominal aorta. This anatomical structure is positioned leftward of the spinal column, encased within a cocoon of adipose tissue behind the peritoneal cavity. It terminates at the L4 vertebra, where it splits into the common iliac arteries. Prior to this bifurcation, the abdominal aorta gives rise to several vital branches.
The celiac trunk, a singular artery, divides into the left gastric artery, which...
The celiac trunk, a singular artery, divides into the left gastric artery, which...
Blood Supply to the Digestive System
Splanchnic circulation refers to the network of blood vessels that supply and drain blood from the abdominal organs involved in digestion, including the stomach, liver, pancreas, intestines, and spleen. This circulation delivers essential nutrients and oxygen while removing waste products from these organs.
Blood Supply to the Digestive System: The splanchnic circulation involves three main arteries: the celiac artery (also known as the celiac trunk) and the superior and inferior mesenteric...
Blood Supply to the Digestive System: The splanchnic circulation involves three main arteries: the celiac artery (also known as the celiac trunk) and the superior and inferior mesenteric...


