関連する実験動画
Updated: Jun 15, 2026

14:26
Progenitor-derived Oligodendrocyte Culture System from Human Fetal Brain
Published on: December 20, 2012
まとめ
普通の乳児の帯血には,しばしば特定の血液凝固活性が含まれています. L型ベンツ=ジョーンズタンパク質を標的とするこの活動は,母体の血液に欠けている場合でも存在し,マクログロブリンと関連しています.
科学分野:
- 免疫学 免疫学とは
- 血液学 ヘマトロジ
- バイオケミストリー バイオケミストリー
背景:
- ベンス・ジョーンズタンパク質は,モノクローナル免疫グロブリンライトチェーンである.
- 生物学的液体における血凝固活性が,免疫反応や分子相互作用を示唆する可能性があります.
研究 の 目的:
- 人間の帯血における血凝固活性の存在と特徴を調査する.
- この活動のターゲット特異性と分子関連性を決定する.
主な方法:
- L型ベンツ=ジョーンズタンパク質でコーティングされた細胞を用いた血液凝固測定法.
- 幼児の帯血と母親の血液における活性比較.
- サハロースのグラデーションで帯血清の超離心分離.
主要な成果:
- 正常な乳児の帯血サンプル54件中47件 (87%) が,血凝固活性を示した.
- この活動は,母親の血液活動とは無関係に帯血で観察されました.
- 超遠心分離により,帯血清のマクログロブリン分体に血栓活性が局所化しました.
結論:
- 人間の帯血には,L型ベンス・ジョーンズタンパク質を標的とした独特の血液凝固因子がしばしば含まれています.
- この因子は,内生的に産生されるか,妊娠中に獲得されるかのようです.
- マクログロブリンとの関連は,IgMや他の大型免疫分子の潜在的な役割を示唆しています.
関連する概念動画
Antibody Structure
Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
Antibody Structure
Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
Transcytosis of IgG
Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
Hybridoma Technology
Hybridoma technology is used for the large-scale production of monoclonal antibodies. Monoclonal antibodies bind to only a single antigenic determinant or epitope. Such antibodies are used in research, diagnostics, and disease therapy. The hybridoma technology established in 1975 by Georges Köhler and Cesar Milstein was awarded the Nobel Prize in Medicine in 1984 for revolutionizing research and therapy.
Hybridoma Selection
Commonly used fusion techniques — electroporation, polyethylene glycol...
Hybridoma Selection
Commonly used fusion techniques — electroporation, polyethylene glycol...
Rh Blood Group
The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
Development of Immunocompetence
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...

