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Updated: Jul 6, 2026

Simultaneous Quantification of Anti-vector and Anti-transgene-Specific CD8+ T Cells Via MHC I Tetramer Staining After Vaccination with a Viral Vector
08:10

Simultaneous Quantification of Anti-vector and Anti-transgene-Specific CD8+ T Cells Via MHC I Tetramer Staining After Vaccination with a Viral Vector

Published on: November 28, 2018

自己MHCに高い親和性を有するT細胞受容体を選択し,CD8の寄与を減少させることで,自己MHCに高い親和性を有するT細胞受容体を選択する

L A Sherman1, S V Hesse, M J Irwin

  • 1Department of Immunology, Scripps Research Institute, La Jolla, CA 92037.

Science (New York, N.Y.)
|October 30, 1992
PubMed
まとめ

CD8核受容体とT細胞の相互作用を変化させることで,自己相容性複合体 (MHC) の afinity が高いT細胞の除去を防ぐことができます. この戦略は,自己MHCと低親和性の抗原を認識するT細胞を生成し,免疫耐性を助けます.

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Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses10:13

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