まとめ
アクロメガリー患者は,特に長期的な疾患または高レベルの成長ホルモンで,左心房高縮などの心臓疾患を発症する可能性があります. これらの心臓の変化は,治療によって回復し,特定のアクロメガリック心筋病変を示唆する可能性があります.
科学分野:
- 心臓病学 心臓病学
- エンドクリノロジー エンドクリノロジー
- 内科内科は,内科の内科である.
背景:
- 過剰な成長ホルモンによって引き起こされる状態であるアクロメガリーは,心血管系の合併症と関連しています.
- 特定の心臓症状とその疾患の重症度との関係を理解することは極めて重要です.
研究 の 目的:
- アクロメガリック患者の心臓異常を調査する.
- 疾患の持続時間や成長ホルモンのレベルなどの心臓機能障害に関連する要因を特定する.
主な方法:
- エコーカルディオグラフィー,フォノカルディオグラフィー,タリウム perfusion スキャニングによるストレスの電気カルディオグラフィー,ゲートされた放射性同位体の左心室血管図を用いた.
- アクロメガリー患者の16人を評価し,心臓の構造と機能を評価した.
主要な成果:
- 併存した高血圧または冠動脈疾患を有する6人の患者は,左心室質量指数の増加と心室機能障害を含む異常を示した.
- 長期にわたるアクロメガリー (>13年) または非常に高い成長ホルモン (>100ng/ml) を有する3人の患者は,左心室の集中性多動症を示し,1人の患者も機能障害を示した.
- 疾患の期間が短く,成長ホルモンのレベルが低く,治療後のレベルが正常化した患者では心臓異常は観察されなかった.
結論:
- アクロメガリーは,冠動脈と高血圧性心臓病の高い罹患率と関連しています.
- アクロメガリーでは,長期にわたる疾患または増加した成長ホルモンレベルが原因で,明確な,潜在的に可逆性心筋症候群が発生することがあります.
関連する概念動画
Structure of Cardiac Muscles
Cardiac muscle, or myocardium, is a specialized type of muscle found exclusively in the heart. Its unique structural and functional characteristics enable the heart to perform its vital role of pumping blood throughout the body continuously and rhythmically. The cardiac muscle cells, or cardiomyocytes, possess an endomysium and perimysium but do not have an epimysium.
Compared to skeletal muscles, cardiac muscle cells are small and mostly have a single nucleus. Additionally, they are usually...
Compared to skeletal muscles, cardiac muscle cells are small and mostly have a single nucleus. Additionally, they are usually...
Overview of the Heart
The heart, a muscular organ located in the chest, functions as the body's pump, circulating blood through the vascular system. It has four chambers: two atria on top and two ventricles below. The right atrium receives deoxygenated blood from the body and passes it to the right ventricle, which pumps it to the lungs for oxygenation. The left atrium receives oxygenated blood from the lungs and transfers it to the left ventricle, which pumps it to the rest of the body.
The heart's structure...
The heart's structure...
Location and Orientation of the Heart
The human heart, despite its modest size and weight, is an organ of remarkable strength and endurance. Roughly the size of a fist, the heart weighs between 250 and 350 grams and is nestled within the mediastinum, the medial cavity of the thorax. It extends obliquely for about 12 to 14 cm, resting on the superior surface of the diaphragm. The heart is positioned anterior to the vertebral column and posterior to the sternum, with two-thirds of its mass lying to the left of the midsternal line.
Imbalances in Cardiac Output
The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send blood...
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send blood...
Heart Failure II: Pathophysiology
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
Cardiomyopathy II: Dilated Cardiomyopathy
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...


