血液凝固因子の毒性 血液凝固因子の毒性
Science (New York, N.Y.)
|August 10, 1962
まとめ
純粋な牛血栓はマウスに毒性があり,オートプロトロンビンCはセファリンと併用したときにのみ致命的であり,プラズマの凝固時間を大幅に短縮しました.
科学分野:
- バイオケミストリー バイオケミストリー
- 血液学 ヘマトロジ
- 毒理学 毒理学 毒理学
背景:
- 牛のトロンビンとオートプロトロンビンCは,血液凝固に不可欠です.
- 彼らの毒性と凝固への影響を理解することは,血静性研究にとって不可欠です.
研究 の 目的:
- ネズミにおける純牛トロンビンとオートプロトロンビンCの毒性を決定する.
- ヒトの血の凝固時間に対するオートプロトロンビンC単独およびセファリンとの効果を調査する.
主な方法:
- ネズミに牛のトロンビンとオートプロトロンビンCを静脈内投与する.
- オートプロトロンビンCと粗製のセファリンを併用する.
- 血の凝固時間をヒトの血サンプルを用いて評価する.
主要な成果:
- 25gのマウスに対する純牛血栓の致死性の静脈内投与量は,50ユニット/mlの溶液の0.4mlでした.
- 単独のオートプロトロンビンCは毒性を示さなかったが,粗製のセファリンと併用すると致命的であった.
- オートプロトロンビンCは単独でヒトの血凝固をわずかに加速させ,セファリンと併用すると凝固時間が5秒に短縮された.
結論:
- 純牛トロンビンはマウスの体内毒性を有意に示しています.
- オートプロトロンビンCは,致命的な毒性を誘発し,血の凝固を著しく加速するために,セファリンなどのコファクターを必要とします.
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