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活性化されたCdc42はc-Cblを隔離し,EGF受容体の分解を防ぐ

Wen Jin Wu1, Shine Tu, Richard A Cerione

  • 1Department of Molecular Medicine, Veterinary Medical Center, Baker Laboratory, Cornell University, Ithaca, NY 14853, USA.

Cell
|September 25, 2003
PubMed
まとめ

Cdc42の活性化は,c-CblによるEGF受容体のユビキチネーションを防止し,これは細胞成長の調節における重要なステップである. 不調は,持続的なシグナル伝達と細胞の変容につながります.

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