健康な高齢の男性におけるダイナミックな運動中の前腕血管収縮の増加
J A Taylor1, G A Hand, D G Johnson
1Department of Exercise and Sport Sciences, University of Arizona, Tucson.
Circulation
|December 1, 1992
まとめ
高齢の男性では,動的運動中に運動していない四肢の血管収縮が増加し,おそらく交感神経系の活動が増加したためである. この発見は,身体活動中に血管制御の年齢関連の変化を示唆しています.
科学分野:
- 心血管生理学 心血管の生理学
- 運動生理学 運動生理学
- 老化に関する研究
背景:
- 運動に対する身体の生理学的反応に対する老化の影響は,重要な研究分野です.
- 動的運動中の年齢とともに,非活動的な四肢の血管収縮がどのように変化するかを理解することは,心臓血管の健康を評価するために重要です.
研究 の 目的:
- 大筋動的運動中の非アクティブの肢体における血管収縮反応が,高齢のヒトにおいて増幅されるかどうかを調査する.
- 運動に対する生理学的反応を若い男性と年配の健康な男性と比較する.
主な方法:
- この研究では,同様の身体活動レベルを持つ16人の若い (26歳) と12人の高齢 (65歳) の健康な男性を対象とした.
- 参加者は,様々なサブマキシマム強度でレパイン・レッグ・サイクリングを行い,研究者は血圧,心拍数,前腕の血流量,血管抵抗,および血のノルエピネフリンとエピネフリンの濃度を測定しました.
主要な成果:
- 年配の男性は,ピークワークロードと酸素の摂取量が低いが,運動に対する血圧の反応は若い男性と比較して同様であった.
- 前腕の血管抵抗は,高齢の男性ではより高く,運動中にアンテキュビタル静脈のノルエピネフリン濃度がより大きく増加しました.
- 前腕の皮膚の血流反応はグループによって似ていたが,運動以外の共感刺激刺激に対する血管圧縮器の反応は,高齢の男性では鈍化していた.
結論:
- 健康な高齢者は,ダイナミックな運動中に前腕の血管収縮が増加し,骨格筋の抵抗血管への同情的な流出の増加によって媒介される可能性が高い.
- これらの発見は,ストレスに対する一般的な過敏反応ではなく,交感性血管圧縮器の調整の年齢関連の変化を示しています.
- 動脈血圧の調節は,研究された健康な高齢の男性では正常であるように見えます.
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