高血圧における心臓と血管の並列適応
1Department of Medicine, New York Hospital-Cornell Medical Center, New York 10021.
Circulation
|December 1, 1992
まとめ
高血圧は,常軌動脈動脈の変化を引き起こします.
科学分野:
- 心血管医学 心血管医学
- 血管生物学 血管生物学
- 高血圧の研究 高血圧の研究
背景:
- 高血圧の血管損傷は合併症に寄与する.
- 動脈の幾何学と,合併症のない高血圧における機能に関する知識は限られている.
- 動脈の変化と左心室縮の関係が不明である.
研究 の 目的:
- 合併症のない高血圧における動脈の幾何学と機能を in vivo で調査する.
- 動脈の変化と左心房縮の関係を探求する.
主な方法:
- 超音波は,43人の高血圧患者と43人の正常血圧患者で,常動脈 (CCA) の壁の厚さと直径を評価した.
- 動脈の圧力の波形から推定された血管の硬さ.
- エコーカルディオグラフィーは,左心室 (LV) のサイズと機能を評価した.
主要な成果:
- 高血圧患者では,LVとCCAの壁の厚さ,およびLVの質量が増加しました.
- 高血圧患者の28%は,頸動脈の内側-中間の厚さが増加した.
- 高血圧患者では,同様の脈圧にもかかわらず,血管の硬さが有意に増加しました.
結論:
- 合併症のない高血圧は,CCAの幾何学的および機能的な変化と関連しています.
- これらの頸動脈の変化は,左心室で観察された変化に並行する.
- これらの血管の変化が高血圧における心血管合併症に与える貢献は,まだ決定されていない.
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