ヴァガル・メカノレフレクスの交感神経活動の制御は,心不全では鈍くなります
M E Dibner-Dunlap1, M D Thames
1Department of Medicine, University Hospitals of Cleveland, Case Western Reserve University, Ohio.
Circulation
|December 1, 1992
まとめ
心不全の犬は,交感神経活動の心肺反射制御の低下を示します. この反射障害は,心臓の状アファレント繊維によって媒介され,バロ受容体や中枢神経系に問題があることを示唆しています.
科学分野:
- 心血管生理学 心血管の生理学
- 自律神経系の規制について
- 心不全 病理生理学 心不全 病理生理学
背景:
- 動脈バロレフレクスの異常は,心不全で知られている.
- 心不全における交感神経活動に対する心肺反射制御については,さらなる調査が必要である.
研究 の 目的:
- 交感神経活動の心肺反射制御が低出力心不全の犬のモデルで異常であるかどうかを判断する.
主な方法:
- 犬における急速心室ペースによる低出力心不全の誘導.
- ボリューム膨張と心房風船膨張を用いた心肺メカニカレセプターの刺激.
- 腎交感神経の活動と血液動力学的圧力の測定.
主要な成果:
- ボリュームの膨張は,心臓不全の犬の腎交感神経の活動が,対照犬と比較して (16%対70%),著しく減少した.
- 心房気球の膨張は,対照群とは異なり,心不全の犬の腎交感神経活動や動脈圧を変化させなかった.
- 弱まった応答は,心臓機能不全の犬において,ベースラインの左心房圧が正常化したときにさえも持続した.
結論:
- 低出力心不全の犬は,同情神経活動の心肺機構反射制御が著しく弱まっている.
- この衰弱は,心臓の静脈系アファレント繊維によって媒介されます.
- 根本的な原因は,心肺神経受容体または中枢神経系処理の異常を含む可能性があります.
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