Pseudomonas aeruginosaに慢性的に感染したシスティック線維症患者のアジトロマイシン:ランダム化制御試験
Lisa Saiman1, Bruce C Marshall, Nicole Mayer-Hamblett
1Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, NY 10032-3784, USA. ls5@columbia.edu
JAMA
|October 2, 2003
まとめ
アジトロマイシンは肺機能を改善し,システィック線維症患者の悪化を軽減しました. このマクロリド抗生物質は,慢性的なPseudomonas aeruginosa感染症を患っている人々にとって潜在的な治療の選択肢を提供します.
科学分野:
- 肺内科 肺内科 肺内科
- 感染症 感染症は感染症です.
- 薬理学 薬理学とは
背景:
- 囊性線維症 (CF) の肺疾患の管理には,抗生物質,粘液除去剤,および抗炎症薬が含まれています.
- マクロリド抗生物質は,CF患者にとって潜在的な利点を示しています.
研究 の 目的:
- アジトロマイシン使用とシスティックフィブロシス (CF) 患者における肺機能との関連性を調査する.
- 慢性的なPseudomonas aeruginosa感染症のCF患者におけるアジトロマイシンの有効性と安全性を評価する.
主な方法:
- マルチセンター,ランダム化,ダブルブラインド,プラセボ対照試験.
- 185人のCF患者 (6歳以上,P.aeruginosa感染,FEV1≥30%) は168日間,口服アジトロマイシンまたはプラセボを投与されました.
- プライマリ・アウトカム:FEV1の変化;セカンダリー・アウトカム:肺の悪化と体重増加.
主要な成果:
- アジスロマイシングループは,FEV1 (0.097 L vs 0.003 L,P=.009) の有意な増加を示しました.
- 肺の悪化のリスクの低下 (HR=0.65,P=.03) と体重増加 (0.7kg,P=.02) がアジトロマイシン群で観察されました.
- アジトロマイシン群で報告された吐き気,下痢,喘息の発生率の増加.
結論:
- アジトロマイシン治療は,CF患者における改善された臨床結果と関連しています.
- 慢性的なP. aeruginosa感染を有するCF患者 (6歳以上) の場合,アジトロマイシンを考慮してください.
- アジトロマイシンは,この患者集団において有利なリスク・利益プロファイルを示しています.
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