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CB1カンナビノイド受容体と,興奮毒性に対するオンデマンド防御
Giovanni Marsicano1, Sharon Goodenough, Krisztina Monory
1Molecular Genetics of Behaviour, Max-Planck-Institute of Psychiatry, Kraepelinstrabetae 2-10, 80804 Munich, Germany.
まとめ
固有のカンナビノイド系は,中枢神経系のニューロンを過度の活動によって引き起こされる損傷から保護します. このシステムは,カンナビノイド受容体1型を含むもので,興奮毒性に対するオンデマンドの保護を提供します.
科学分野:
- 神経科学は神経科学である.
- 神経薬理学神経薬理学について
- セルラー・シグナリング
背景:
- 異常なニューロンの発火は,神経損傷につながる可能性があります.
- このような活動に対して保護的なシグナルシステムの存在が仮定されている.
研究 の 目的:
- 前脳ニューロンを興奮毒性から保護する内生カンナビノイドシステムの役割を調査する.
- カナビノイド受容体1型 (CB1) のシグナル伝達が神経保護に不可欠であるかどうかを判断する.
主な方法:
- 主要な前頭脳ニューロンにCB1が欠けている条件付き変異性マウスを生成した.
- カイン酸 (KA) を投与して,発作を誘発し,excitotoxicity in vivo および in vitro.
- 測定された神経刺激の値と海馬のアナンドマイド濃度.
主要な成果:
- 変異したマウスは,KA投与後に過剰な発作と刺激の値の低下を示した.
- KAは野生型のマウスのヒポカンパのアナンドマイドレベルを急速に増加させた.
- KA誘発の保護機構は突然変異したマウスには存在せず,CB1媒介のシグナル伝達に障害があることを示した.
結論:
- 内生カンナビノイド系は,CB1受容体を通して,急性興奮毒性に対する重要なオンデマンド神経保護を提供します.
- カンナビノイド系を標的とした治療は,神経の過興奮や損傷を含む疾患の治療戦略を提供することができる.
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