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スルファチド:反フォスフォリピド抗体の標的である

M Merten¹, S Motamedy, S Ramamurthy

¹Departments of Pathology and Medicine, Baylor College of Medicine, Houston, Tex, USA.

|October 8, 2003

まとめ

Beta2-glycoprotein Iは硫酸塩と結合し,これらの分子が反フォスフォリピド抗体の標的であることを示唆しています. この相互作用は,抗リンパ脂抗体症候群に関連する臨床症状を説明する可能性がある.

科学分野:

免疫学免疫学とは
グライコバイオロジーは,
血液学ヘマトロジ

背景:

スルファチドは,血液細胞の表面にあるグルコスフィンゴリピドであり,血液静止に関与する.
Beta2-glycoprotein Iはアニオン系フォスホリピドと結合し,抗フォスホリピド抗体によって標的にされ,血栓形成と流産に関連しています.

研究の目的:

ベータ2-グリコプロテインIが硫化物と複合体を形成するかどうかを調査する.
これらの複合体が,抗フォスホリピド抗体の標的であるかどうかを判断する.

主な方法:

ELISAはβ2-グリコプロテインIの硫化物との結合を測定する測定法である.
抗カルジオリピン抗体を含む患者の血清を,硫酸塩結合ベータ2グリコプロテインIの反応性について検査する.

主要な成果:

ベータ2-グリコプロテインIは,他のグリコリピドではなく,表面に結合した硫化物と特異的に結合します.
抗カルジオリピン抗体を持つ患者の血清は,硫酸塩ベータ2-グリコプロテインI複合体との反応性を示した.
浄化された抗カルジオリピン抗体も複合体と反応した.

結論:

サルファチドは,アニオン系フォスホリピドに加えて,反フォスホリピド抗体の標的である.
サルファチドとの抗体相互作用は,抗リンパ脂抗体症候群の症状に寄与する可能性があります.

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