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Updated: May 5, 2026

Live-imaging of PKC Translocation in Sf9 Cells and in Aplysia Sensory Neurons
09:54

Live-imaging of PKC Translocation in Sf9 Cells and in Aplysia Sensory Neurons

Published on: April 6, 2011

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PKAによるRIM1alphaのリン酸化は,小脳並列繊維シナプスにおけるシナプス前長期増強を誘発する

György Lonart1, Susanne Schoch, Pascal S Kaeser

  • 1Center for Basic Neuroscience, Department of Molecular Genetics and Howard Hughes Medical Institute, UT Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA.

Cell
|October 9, 2003
PubMed
まとめ

タンパク質キナーゼA (PKA) は,主要な活性ゾーンタンパク質であるRIM1alphaを直接リン酸化して,小脳シナプスにおけるプレシナプス長期増強 (LTP) を誘導する. 特定の部位でのこのリン酸化は,LTP誘導に極めて重要です.

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Long-term Potentiation01:35

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Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
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Many proteins in the cell are regulated by phosphorylation, the addition of a phosphate group. A family of enzymes called kinases...
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Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
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Membrane lipids such as phosphatidylinositol (PI) are precursors for several membrane-bound and soluble second messengers. Specific kinases phosphorylate PI and produce phosphorylated inositol phospholipids. One such inositol phospholipids are the  phosphatidylinositol-4,5 bisphosphate [PI(4,5)P2], present in the inner half of the lipid bilayer. Upon ligand binding, GPCR stimulates Gq proteins to turn on phospholipase Cꞵ. Activated phospholipase Cꞵ cleaves PI(4,5)P2 and...
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Calmodulin-dependent Signaling

Calmodulin (CaM) is a calcium-binding protein in eukaryotes that controls various calcium-regulated cellular processes. It has four calcium-binding sites that bind calcium to form the calcium-calmodulin ( Ca2+-CaM) complex. GPCR stimulation increases the calcium levels in the cells that bind to CaM and induces a conformational change.
The Ca2+-CaM complex does not have enzymatic activity by itself. Instead, the complex binds downstream target proteins, including membrane proteins or enzymes,...
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