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Updated: Jun 28, 2026

Determination of the Relative Potency of an Anti-TNF Monoclonal Antibody (mAb) by Neutralizing TNF Using an In Vitro Bioanalytical Method
16:07

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Published on: September 16, 2017

TNFαα誘発のアポプトシスには,JNK依存の経路が必要である

Yibin Deng1, Xiaoyang Ren, Lin Yang

  • 1Huffington Center on Aging and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 70030, USA.

Cell
|October 9, 2003
PubMed
まとめ

腫瘍死滅因子 (TNFalpha) 信号はJNKを活性化させ,JNKは Bid. これはSmac/DIABLOを放出し,抑制を緩和し,アポトーシスのためのカスパース8の活性化を可能にします.

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