エキノカンジンの抗真菌薬は,

David W Denning¹

¹Education and Research Centre, Wythenshawe Hospital, Southmoor Road, M23 9LT, Manchester, UK. ddenning@man.ac.uk

Lancet (London, England)

|October 11, 2003

まとめ

エキノカンジンは,真菌細胞壁の合成を阻害する抗真菌薬です. 伝統的な抗真菌薬と比較して副作用が少ない効果的な治療法として有望であることが示されています.

科学分野:

薬理学薬理学とは
菌類学菌類学とは

背景:

エキノカンジンは,ベータ-1,3-グルカンの合成を標的としたリポペプチド抗真菌剤です.
このメカニズムは,真菌の細胞壁を損傷させ,真菌殺菌または真菌滅菌効果をもたらします.

研究の目的:

エキノカンジンの性質と臨床応用について検討する.
既存の抗真菌療法との効果と安全性を比較する.

主な方法:

in vitroおよびin vivoの研究に関する文献レビュー.
カスポフンジンとミカフンギンの臨床試験データの分析.
薬理動力学および薬理動力学的性質の評価.

主要な成果:

エキノカンジンは,Candida spp. に対して有効です. そして,アスペルギルス spp. しかし,Zygomycetes,Cryptococcus neoformans,またはFusarium spp.は含まれていない.
カスポフンジンは,耐火性侵襲性アスペルギロシスにおける40%の応答率を示した.
研究によると,エキノカンジンは安全性プロファイルが向上したアンフォテリシンBと同等の有効性を有していることが示唆されています.

結論:

エキノカンジンは,好ましい安全性プロファイルを提供し,静脈内投与に適しています.
限られた薬物相互作用と1日1回投与は,それらの臨床的有用性を高めます.
他の抗真菌薬,特に侵入性アスペルギロシスの併用療法の可能性.

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