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Defining Substrate Specificities for Lipase and Phospholipase Candidates
Published on: November 23, 2016
ユニークなリポプロテインのフェノタイプとゲノタイプは,例外的な長寿と関連しています
Nir Barzilai1, Gil Atzmon, Clyde Schechter
1Institute for Aging Research, Diabetes Research and Training Center, Albert Einstein College of Medicine, New York, NY 10461, USA. barzilai@aecom.yu.edu
JAMA
|October 16, 2003
まとめ
特殊な寿命は,より大きな高密度リポプロテイン (HDL) と低密度リポプロテイン (LDL) の粒子のサイズに関連しています. この遺伝的特徴は,特定の遺伝子変異と関連しており,健康的な老化を促し,疾患リスクを軽減します.
科学分野:
- 遺伝学 遺伝学とは
- ゲロントロジーはゲロントロジーの学科です.
- 心血管科学 心血管科学
背景:
- 特殊な長寿は,年齢関連の疾患の遅発と関連しています.
- 長生き者の家族には,老化や病気の感受性に影響を与える要因が遺伝する可能性があります.
研究 の 目的:
- 人間の長寿現象型を定義する生物学的および遺伝的要因を特定する.
- 長寿におけるリポプロテイン粒子のサイズとCETP遺伝子変異の役割を調査する.
主な方法:
- 特殊な長寿を持つアシュケナジ・ユダヤ人のプロバンドとその子孫を,年齢に匹敵するコントロールと比較したケース・コントロール研究.
- プロトン核磁気共振を用いた脂質および脂質タンパク質亜クラスの粒子の大きさの分析.
- コレステリルエステル転送タンパク質 (CETP) I405V遺伝子変異のゲノタイプ化.
主要な成果:
- 試験対象者とその子孫は,対照群と比較して,HDLとLDLの粒子のサイズが著しく大きかった.
- より大きなリポプロテイン粒子のサイズは,高血圧,心血管疾患,代謝症候群のより低い罹患率と関連していました.
- CETP405バリンアレル (VV遺伝子型) のホモジゴシティの頻度の増加は,プロバンドと子孫で観察されました.
結論:
- より大きなHDLおよびLDL粒子の大きさは,例外的な長寿と関連付けられた遺伝的フェノタイプです.
- このリポプロテインフェノタイプは,年齢に関連する疾患のリスクの低下と相関しています.
- CETP I405Vの変種は,健康的な老化フェノタイプを促進する役割を果たす可能性があります.
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