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Updated: May 23, 2026

DamID-seq: Genome-wide Mapping of Protein-DNA Interactions by High Throughput Sequencing of Adenine-methylated DNA Fragments
09:14

DamID-seq: Genome-wide Mapping of Protein-DNA Interactions by High Throughput Sequencing of Adenine-methylated DNA Fragments

Published on: January 28, 2016

ホメオドメインの相互作用タンパク質キナーゼ2は,転写性コアプレッサーCtBPのダウンレギュレーションによってアポトーシスを促進する

Qinghong Zhang1, Yasuhiro Yoshimatsu, Jeffrey Hildebrand

  • 1Vollum Institute, Oregon Health and Science University, 3181 S.W. Sam Jackson Park Road, Portland, OR 97239, USA. zhangq@ohsu.edu

Cell
|October 22, 2003
PubMed
まとめ

CtBP (C末端結合タンパク質) の遺伝的ノックアウトは,アポトーシスを増加させます. 紫外線とHIPK2 (ホメオドメイン相互作用タンパク質キナーゼ2) は,CtBPレベルを低下させ,p53-欠乏細胞におけるアポトーシスを促進する.

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