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Updated: Jul 5, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
10:33

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

Rab GDP解離阻害剤とプレニル化YPT1GTPアゼとの複合体の構造

Alexey Rak1, Olena Pylypenko, Thomas Durek

  • 1Department of Physical Biochemistry, Max-Planck-Institute for Molecular Physiology, Otto-Hahn-Strasse 11, 44227 Dortmund, Germany.

Science (New York, N.Y.)
|October 25, 2003
PubMed
まとめ

モノプレニレートされたYpt1:RabGDI複合体の構造を決定し,RabGDIがRabタンパク質によるヌクレオチド放出を阻害する方法を明らかにし,人間の精神的遅滞に関連した変異の洞察を提供しました.

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Monitoring GPCR-β-arrestin1/2 Interactions in Real Time Living Systems to Accelerate Drug Discovery

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