高血圧の被験者におけるインスリン感受性およびグリコゲン代謝に対する強烈かつ長期間の運動の影響
Caroline Rhéaume1, Paulo-Henrique Waib, N'Guessan Kouamé
1Hypertension, University Hospital Research Center, Québec, Canada G1R 2J6.
Circulation
|October 29, 2003
まとめ
高血圧は,インスリン感受性の低下と関連していますが,筋肉のグリコゲン貯蔵と運動後の再合成の速度が向上しています. これらの適応は,高血圧患者における炭水化物の代謝障害を補う可能性がある.
科学分野:
- 運動生理学 運動生理学
- メタボリック・ヘルス (代謝の健康)
- 心血管疾患 心血管疾患
背景:
- インスリン感受性およびグリコゲン合成は,主にインスリン輸注研究に基づいて,高血圧で低下したと報告されています.
- 高血圧患者のグリコゲン代謝に長期間の運動が与える影響は不明である.
研究 の 目的:
- 長期の運動中およびその後,高血圧および正常血圧の被験者のグリコゲン代謝とインスリン感受性を調査する.
- 高血圧におけるグリコゲン代謝の変化が血流や補償メカニズムと関連しているかどうかを判断する.
主な方法:
- 9人の高血圧と11人の正常血圧の被験者を,休息日と長期の運動の後で評価した.
- 測定されたインスリン感受性,血液動力学的変数,全身基板利用,および筋肉のグリコゲン.
- グリコーゲン含有量および静止状態および運動後のグリコーゲン合成酵素活性に対する筋肉バイオプシの評価.
主要な成果:
- 高血圧の被験者は,休息時のインスリン感受性が低く,運動中に炭水化物の利用量が減少した.
- 低インスリン感受性にもかかわらず,高血圧の個人は,ベースラインの筋肉のグリコゲン値が高く,運動後のグリコゲン再合成が速くなりました.
- 高血圧の被験者では,血流の変化とは無関係に,グリコゲン濃度が減少し,より早く回復した.
結論:
- 高血圧における筋肉内グルコゲン貯蔵と再合成の増加は,補償的メカニズムであるように思われる.
- これらの適応は,高血圧の個人にインスリン感受性の低下と炭水化物の代謝障害を相殺する可能性があります.
- 高血圧におけるグリコゲン代謝の調整は,足の血流の変化にのみ依存するものではありません.
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