前進するために過去を振り返る:神経変性障害の早期発見

Steven T DeKosky¹, Kenneth Marek

¹Department of Neurology and Alzheimer Disease Research Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. DeKoskyST@upmc.edu

Science (New York, N.Y.)

|November 1, 2003

まとめ

アルツハイマー病やパーキンソン病などの神経変性疾患の早期発見は,新しい分子神経科学のツールによって可能になっています. これにより,症状前の診断と,早期に疾患を修正する治療法の開発が可能になります.

科学分野:

神経科学は神経科学である.
医療診断医療診断
病理生物学パトバイオロジー

背景:

アルツハイマー病やパーキンソン病を含む神経変性疾患は,ゆっくり進行する.
早期発見は,病気のメカニズムを理解し,患者のアウトカムを改善するために不可欠です.
現在の診断と治療戦略は,臨床症状が現れた後にしばしば開始されます.

研究の目的:

神経退行性疾患の早期発見のための分子神経科学における最近の進歩の可能性を強調する.
患者の治療と疾患管理のための症状前診断の利点を強調する.
病気の病理生物学を理解する上で,新興ツールが果たす役割について議論する.

主な方法:

病気の予備性に対する遺伝的マーカーの利用.
構造的および機能的分析のための高度な神経イメージング技術を使用します.
病気特有のバイオマーカーを特定するために生化学的測定法を適用する.
総合的な患者評価のための臨床評価を統合する.

主要な成果:

様々な遺伝子,イメージング,臨床,生化学のツールの検証研究は進行中です.
これらのツールは,臨床的表れの前に神経変性疾患を検出する有望なことを示しています.
病気の発症の前症状の指標を特定するうえで進展が進んでいます.

結論:

神経変性疾患の早期発見は,分子神経科学の進歩によって達成可能である.
症状前の診断は,介入のための重要な窓を提供します.
早期および前症候群での使用のための疾患修正薬の開発は,重要な将来の目標です.

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