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Integrated Compensatory Responses in a Human Model of Hemorrhage
Published on: November 20, 2016
姿勢が血液や眼内圧に与える影響 多発性系性縮,純粋自律性障害,バロレフレクスの機能不全
Chasidy D Singleton1, David Robertson, Daniel W Byrne
1Department of Ophthalmology and Visual Sciences, Vanderbilt University Medical Center, Nashville, Tenn,. USA.
Circulation
|November 5, 2003
まとめ
自律機能障害のある患者は,ポジションを変更する際に,平均動脈圧 (MAP) と眼内圧 (IOP) の両方が著しく低下します. これは,自律神経系がIOPの調節に重要な役割を果たしていることを示唆しています.
科学分野:
- オフタルモロジック (眼科)
- 神経学 神経学とは
- 心血管生理学 心血管の生理学
背景:
- 眼内圧 (IOP) 調節には,全身的血管制御が含まれることがあります.
- 自律的機能障害は,生理学的調節に影響を与える可能性があります.
- 眼圧と全身圧の関連性を理解することは極めて重要です.
研究 の 目的:
- 自律機能不全の患者における血圧と眼内圧の相関を調査する.
- 自律的機能障害が,全身的および眼圧の関係を変化させるかどうかを判断する.
主な方法:
- IOP,血圧 (シストリック,ダイアストリック,MAP) と心拍を横,座り,立っている状態で比較した.
- 多発性システム縮,純粋自律機能不全,またはバロレフレクスの不全の11人の患者が含まれており,年齢/性別がマッチした対照群も含まれていました.
- 一般的な線形モデルを用いてデータを分析し,繰り返し測定するANOVA.
主要な成果:
- 自律機能障害のある患者は,横から立った状態からMAP (31 mm Hg) とIOP (6 mm Hg) の有意な低下を示した (P<0.001).
- コントロールは,位置の変化でMAP (+4 mm Hg) とIOP (1 mm Hg) の最小限の変化を示した.
- 姿勢の変化 (P=0.648) の間,患者と対照群の間で,有意な心拍の変化は観察されなかった.
結論:
- 平均動脈圧 (MAP) の大幅な低下は,自律機能不全の患者の眼内圧 (IOP) の有意な低下と相関する.
- これらの発見は,潜在的に全身の血圧の影響を通じて,IOPの調節における自律神経系の重要な役割を果たしていることを示しています.
キーワード:
非プログラム的なものです.関連する概念動画
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