関連する実験動画

Updated: Jun 23, 2026

Techniques to Induce and Quantify Cellular Senescence
06:51

Techniques to Induce and Quantify Cellular Senescence

Published on: May 1, 2017

テロメア誘発の衰老におけるDNA損傷チェックポイント反応

Fabrizio d'Adda di Fagagna1, Philip M Reaper, Lorena Clay-Farrace

  • 1[1] The Wellcome Trust/Cancer Research UK Institute of Cancer and Developmental Biology, University of Cambridge, Cambridge CB2 1QR, UK [2] Present address: IFOM-FIRC Institute of Molecular Oncology, via Adamello 16, 20139 Milan, Italy.

Nature
|November 11, 2003
PubMed
まとめ

細胞老化,つまり増殖の可能性の喪失は,染色体末端 (テロメア) のDNA損傷と関連しています. 機能不全のテロメアは,DNA損傷のチェックポイントを活性化し,細胞分裂を停止させます. この研究は,テロメアの機能不全が老化の重要な要因であることを明らかにしています.

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