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Updated: Jul 7, 2026

Evaluation of Keratinocyte Proliferation on Two- and Three-dimensional Type I Collagen Substrates
08:19

Evaluation of Keratinocyte Proliferation on Two- and Three-dimensional Type I Collagen Substrates

Published on: April 22, 2019

残留リポプロテイン誘発の滑らかな筋肉細胞の増殖には,表皮成長因子受容体のトランザクティベーションが含まれます

Akio Kawakami1, Akira Tanaka, Tsuyoshi Chiba

  • 1Department of Medical Biochemistry, Graduate School of Medicine, Tokyo Medical and Dental University, 1-5-45, Yushima, Building D-256, Bunkyo-ku, Tokyo 113-8519, Japan.

Circulation
|November 19, 2003
PubMed
まとめ

残留リポタンパク質 (RLP) は,表皮成長因子 (EGF) 受容体経路を活性化することによって,滑らかな筋肉細胞 (SMC) の増殖を促進します. このメカニズムには,タンパク質キナーゼC (PKC) とヘパリン結合型EGFのような成長因子 (HB-EGF) の流出が関与し,動脈硬化症の発症に寄与する.

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