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Milk Collection Methods for Mice and Reeves' Muntjac Deer
Published on: July 19, 2014
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哺乳類の甘い味とウマミ味の受容体は
Grace Q Zhao1, Yifeng Zhang, Mark A Hoon
1Howard Hughes Medical Institute and Departments of Biology and Neurosciences, University of California at San Diego, La Jolla, CA 92093, USA.
Cell
|November 26, 2003
まとめ
この研究では,T1R受容体がマウスの甘やウマミの味覚に不可欠であることを示しています. 特定のT1Rサブユニットを除去すると,味覚検出が変化し,味覚モダリティ感知における重要な役割が証明された.
科学分野:
- 神経科学は神経科学である.
- 感覚生物学 感覚生物学について
- 遺伝学 遺伝学とは
背景:
- 甘い味とウマミの味は,人間における重要な魅力的な感覚の様式である.
- T1R受容体,特にT1R1+3 (ウマミ) とT1R2+3 (甘い) は,これらの味覚を決定するGタンパク質結合受容体候補である.
研究 の 目的:
- 味覚におけるT1R1,T1R2,T1R3の行動的,生理学的役割を特徴づける.
- 甘い味の認識とニューラルコーディングの分子基礎を調査する.
主な方法:
- T1R1,T1R2,T1R3のノックアウトマウスの生成と分析.
- 人間のT1R2 (hT1R2) または改変されたオピオイド受容体 (RASSL) を甘さ感受性細胞に発現させるためのエンジニアリングマウス.
主要な成果:
- 甘いものやウマミの味覚は,T1R受容体に依存している.
- T1Rサブユニットの選択的な削除は,甘い味とウマミの味の検出と知覚を差異的に低下させた.
- マウスにおけるhT1R2の発現は,人間に似た甘い味の好みを引き起こした.
- 甘い細胞におけるRASSLの発現は,合成オピエイトへの魅力を誘発した.
結論:
- T1R受容体は,甘味とウマミの味の検出と知覚に不可欠です.
- 甘い味の細胞の選択性は,単に細胞タイプによってではなく,その細胞が発現する特定の受容体によって決定されます.
- これらの発見は,特定の味の様式を媒介し,味の好みを形成するT1Rサブユニットの重要な役割を強調しています.
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