コリオアムニオニオチスと脳性麻痺は,期末および期末期の乳児におけるものです
Yvonne W Wu1, Gabriel J Escobar, Judith K Grether
1Department of Neurology, University of California, San Francisco 94143, USA. wuy@peds.ucsf.edu
JAMA
|December 4, 2003
まとめ
クリニカル・コリオアムニオニエチス (Clinical chorioamnionitis) は,妊娠期および妊娠間近の乳児における脳性麻痺 (CP) の独立した危険因子である. この発見は,CPの発生率を減らすために,コリオアムニオニ炎に対処することの重要性を強調しています.
科学分野:
- 神経学 神経学とは
- 産科は産婦人科です.
- 小児科は小児科です.
背景:
- 脳性麻痺 (CP) は,多くの妊娠中の乳児に影響しますが,リスク要因は不明です.
- 新興の証拠は,コリオアムニオニ炎がCPの発達に役割を果たす可能性があることを示唆しています.
研究 の 目的:
- クリニカルコリオアムニオニオチスと期末および期末期の乳児におけるCPのリスクとの関連性を調査する.
主な方法:
- 妊娠36週以上で生まれたシングルトン乳児の大きなコホートの中で,症例対照研究が行われました.
- 症例は中等度から重度のCPを有する子供であり,対照群はランダムに選択された.
- 臨床的なホリオアムニオニエチスは,主治医によって診断されました.
主要な成果:
- コリオアムニオニオイティスは,CP症例の14%で,対照群の4%に存在していた (OR, 3.8).
- CPの独立した危険因子には,コリオアムニオン炎 (OR,4.1),子宮内成長制限,母親の民族性,母親の年齢,およびヌリパリティが含まれています.
- コリオアムニオニエチスは,CPの集団に起因する分数の11%を占めました.
結論:
- クリニカル・コリオアムニオニエチス (Clinical chorioamnionitis) は,妊娠期および妊娠間近の乳児における脳性麻痺の独立した危険因子である.
- これらの発見は,CPを予防するためにコリオアムニオニ炎を標的とした介入の必要性を強調しています.
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