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MAP2とtauの投射ドメインは,デンドライトと軸索のマイクロチューブル間の間隔を決定する

J Chen¹, Y Kanai, N J Cowan

¹Department of Anatomy and Cell Biology, School of Medicine, University of Tokyo, Japan.

|December 17, 1992

まとめ

MAP2,MAP2C,tauのような微小管に関連するタンパク質 (MAPs) は,ニューロン構造に影響を与えます. 異なるMAPは, dendriticまたはaxonalの組織を模倣して,明確なマイクロチューブル間隔を作成します.

科学分野:

神経科学は神経科学である.
細胞生物学細胞生物学
分子生物学は分子生物学である.

背景:

ニューロンは, dendrites と axons. 独特の偏極化された構造を示しています.
デンドライトとアクソンには,マイクロチューブルとマイクロチューブル関連タンパク質 (MAP) が含まれています.
MAP2は主にデンドライトに存在し,MAP2Cとタウは軸索に豊富に存在する.

研究の目的:

マイクロチューブル組織に対するMAP2,MAP2C,tauの影響を調査する.
異なるMAPを発現する細胞における微小管の配置を比較する.

主な方法:

Sf9昆虫細胞におけるMAP2とMAP2Cの発現.
MAP2,MAP2C,tauを発現するSf9細胞における微小管組織の比較.
マイクロチューブルの間隔と形態学の分析.

主要な成果:

微小管の間隔は,特定のMAPによって決定される.
MAP2発現は,デンドライトに似た微小管の間隔を生じさせた.
MAP2Cとtauの発現は,軸索の特徴であるマイクロチューブル間隔を引き起こした.

結論:

MAPは,神経細胞内の微小管領域を明確に確立する上で重要な役割を果たします.
MAPの微分表現は,デンドライトと軸索のユニークな構造的組織に寄与する.

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