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関連する概念動画

Mate Choice01:20

Mate Choice

Mate choice—the decision about whom to mate with—is a type of natural selection, since animals must reproduce to pass down their genes. Mate choice is also called intersexual selection because the behavior occurs between the sexes.
Chemotaxis and Direction of Cell Migration01:21

Chemotaxis and Direction of Cell Migration

Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon towards...
Selectins01:25

Selectins

Cell adhesion is  an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain, which...
Cellular Differentiation00:57

Cellular Differentiation

How does a complex organism such as a human develop from a single cell? It all starts from a single fertilized egg which gives rise to a vast array of cell types, such as nerve cells, muscle cells, and epithelial cells that characterize the adult? Throughout development and adulthood, cellular differentiation leads cells to assume their final morphology and physiology. Differentiation is the process by which unspecialized cells become specialized to carry out distinct functions.
A zygote is a...
Target Cell Response to Hormones01:22

Target Cell Response to Hormones

Hormones intricately bind to receptors on the surface or within target cells, initiating a cascade of cellular responses.
Notably, the cellular response can be regulated by altering the number of receptors expressed in the cell. For example, prolonged exposure to elevated hormone levels results in a gradual decline or down-regulation in the number of receptors for that specific hormone on the cell surface. Conversely, in response to low hormone levels, cells may use up-regulation, producing an...
Natural Selection and Mating Preferences01:06

Natural Selection and Mating Preferences

The principle of natural selection posits that organisms better adapted to their environment are more likely to survive and reproduce. This principle is closely intertwined with mating preferences, a key aspect of sexual selection, which evolutionary psychologists believe is driven by instincts to propagate one's genes. Such instincts significantly influence mating behaviors and preferences between genders.
Females, due to their biological roles in conception, pregnancy, and nursing, inherently...

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関連する実験動画

Updated: Jul 16, 2026

A Rapid Filter Insert-based 3D Culture System for Primary Prostate Cell Differentiation
09:23

A Rapid Filter Insert-based 3D Culture System for Primary Prostate Cell Differentiation

Published on: February 13, 2017

ティモサイト陽性選択を誘発できる細胞系.

P Hugo1, J W Kappler, D I Godfrey

  • 1Howard Hughes Medical Institute, National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado 80206.

Nature
|December 17, 1992
PubMed
まとめ

この研究は,特定の甲状腺上皮細胞がT細胞を選択できることを示しています. これらの細胞は,メジャー・ヒストコンパティビリティ・コンプレックス (MHC) タンパク質を通じて抗原を提示し,T細胞の発達を導く.

科学分野:

  • 免疫学 免疫学とは
  • 細胞生物学 細胞生物学

背景:

  • 胸腺は,陽性選択を含むT細胞発育に不可欠です.
  • 陽性選択は,T細胞が自己メジャーヒストコンパティビリティコンプレックス (MHC) タンパク質を認識することを保証します.
  • 胸膜の陽性選択を媒介する特定の細胞タイプは,まだ完全に理解されていません.

研究 の 目的:

  • 特殊な胸膜上皮細胞がT細胞の陽性選択を媒介するかどうかを調査する.
  • 導入された上皮細胞がポジティブ・セレクションをサポートできるかどうかを判断する.

主な方法:

  • 放射線を受けたマウスは,骨髄または胎児の肝臓細胞で再構成された.
  • H-2bを発現するタイミック上皮細胞系が,H-2kを受容したマウスに導入されました.
  • T細胞受容体の認識と制限を分析した.

主要な成果:

  • I-Ab-制限のT細胞の存在は,受容体動物で検出されました.
  • これは,導入されたH-2bを発現する上皮細胞が正の選択を成功裏に媒介したことを示している.
  • T細胞選択における特定の上皮細胞の能力を実証する.

結論:

さらに関連する動画

Evaluating the Differentiation Capacity of Mouse Prostate Epithelial Cells Using Organoid Culture
10:38

Evaluating the Differentiation Capacity of Mouse Prostate Epithelial Cells Using Organoid Culture

Published on: November 22, 2019

An Efficient Method for Directed Hepatocyte-Like Cell Induction from Human Embryonic Stem Cells
08:05

An Efficient Method for Directed Hepatocyte-Like Cell Induction from Human Embryonic Stem Cells

Published on: May 6, 2021

関連する実験動画

Last Updated: Jul 16, 2026

A Rapid Filter Insert-based 3D Culture System for Primary Prostate Cell Differentiation
09:23

A Rapid Filter Insert-based 3D Culture System for Primary Prostate Cell Differentiation

Published on: February 13, 2017

Evaluating the Differentiation Capacity of Mouse Prostate Epithelial Cells Using Organoid Culture
10:38

Evaluating the Differentiation Capacity of Mouse Prostate Epithelial Cells Using Organoid Culture

Published on: November 22, 2019

An Efficient Method for Directed Hepatocyte-Like Cell Induction from Human Embryonic Stem Cells
08:05

An Efficient Method for Directed Hepatocyte-Like Cell Induction from Human Embryonic Stem Cells

Published on: May 6, 2021

  • 特定の甲状腺上皮細胞は,T細胞の陽性選択を媒介するのに十分である.
  • この発見は,胸腺内のT細胞発達の細胞的基礎を明らかにしている.
  • 適応免疫における上皮細胞サブセットの役割を強調する.