チンク指の転写活性化剤であるチャーチルは,胃細胞と神経細胞の間の移行を調節する

Guojun Sheng¹, Mario dos Reis, Claudio D Stern

¹Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom.

Cell

|December 4, 2003

まとめ

線維芽生殖成長因子 (FGF) 信号伝達は,胚の発達にとって極めて重要です. 新しいタンパク質,チャーチル (ChCh) は,FGFFを調節するスイッチとして機能し,FGFFを調節します.

科学分野:

発達生物学発達生物学とは
分子および細胞生物学は,分子および細胞生物学である.

背景:

胃化は,表皮質からメソダームとエンドダームを確立します.
神経板の形成は, gastrulation の直後に起こります.
この2つのプロセスは,繊維細胞成長因子 (FGF) 信号伝達に依存しています.

研究の目的:

初期の胚発達におけるFGFのシグナル伝達役割を制御する分子スイッチを特定する.
FGFシグナリングがメソデームとニューラル運命を区別するメカニズムを解明する.

主な方法:

新しい亜鉛指の転写活性化剤の説明,チャーチル (ChCh).
FGF誘発遺伝子発現を調節するChChの役割の分析.
ガストルーレーション中の細胞移動と侵入におけるChChの機能の調査.

主要な成果:

チャーチル (ChCh) は,FGFのシグナル伝達のためのスイッチとして機能し,異なる発達結果を媒介します.
FGFによるChChの遅い誘導は,Smad相互作用タンパク質-1 (Sip1) の活性化につながります.
ChChによって調節されるSip1は,FGFによるメソダーママーカー誘導を抑制し,神経誘導を促進します.

結論:

神経誘導は,メソダームの形成が中間線で停止することを要求する.
チャーチル (ChCh) は,適切な生殖層の仕様のためのFGF信号の調整に重要な役割を果たします.
ChChによって調節されるFGFシグナリングは,BMPシグナルに対する細胞の感受性を高め,発達上の決定に影響を与えます.

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