P2Y12 H2ハプロタイプは,外周動脈疾患と関連している:ケース・コントロール研究
Pierre Fontana1, Pascale Gaussem, Martine Aiach
1INSERM U.428, Hôpital Européen Georges Pompidou et Université Paris V, Paris, France.
Circulation
|December 10, 2003
まとめ
血小板の蓄積の増加に関連したP2Y12 H2ハプロタイプは,外周動脈疾患 (PAD) の患者でより一般的です. この発見は,この遺伝的変異が動脈硬化症の発達における潜在的な役割を示唆しています.
科学分野:
- 心血管の遺伝学について
- 血小板生物学 血小板生物学について
- 動脈硬化症の研究研究
背景:
- 機能獲得P2Y12遺伝子ハプロタイプ (H2) は,アデノシン・ディフォスファート (ADP) 誘発による血小板凝集を増加させる.
- 血小板は,動脈硬化症と動脈血栓症において極めて重要です.
研究 の 目的:
- P2Y12 H2ハプロタイプと周辺動脈疾患 (PAD) のリスクとの関連を調査する.
主な方法:
- 184人の男性PAD患者と330人の年齢マッチングした対照群を対象としたケース・コントロール研究.
- P2Y12 H2ハプロタイプのゲノタイプ化と,症例対対照群におけるその頻度の分析.
- 心血管疾患のリスク要因に調整された多変量回帰分析.
主要な成果:
- H2ハプロタイプは,対照群 (21%),PAD患者 (30%) に比べて有意に頻繁であった.
- 単変数解析では,オッズ比 (OR) が1.6であった (95%CI,1.1-2.5;P=0.02).
- 多変量分析は,調整後の2.3 (95%CI,1.4-3.9;P=0.002) のORで,関連性を確認しました.
結論:
- P2Y12 H2ハプロタイプは,外周動脈疾患のリスクの増加と関連しています.
- これらの発見は,動脈硬化症におけるH2ハプロタイプの役割を示唆しています.
- P2Y12 H2ハプロタイプのキャリアは,チエノピリジンに対する相対的な耐性を示す可能性があります.
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