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動脈の硬直,波反射,冠動脈疾患のリスク
Thomas Weber1, Johann Auer, Michael F O'Rourke
1Cardiology Department of the General Hospital of the Kreuzschwestern, Wels, Austria. thomas.weber@khwels.at
Circulation
|December 10, 2003
まとめ
拡張指数 (AIx) のような非侵襲的な動脈硬さの測定は,特に若い男性において,冠動脈疾患のリスクを強く予測します. これは,心血管疾患の貴重なスクリーニングツールを提供します.
科学分野:
- 心血管医学 心血管医学
- バイオメディカルエンジニアリング
- 血管生理学 血管生理学
背景:
- 侵襲的な動脈硬度測定は冠動脈動脈硬化症を予測しますが,広範なスクリーニングには非現実的です.
- 大規模な患者集団における効率的なリスク分層化には,非侵襲的な方法が必要です.
研究 の 目的:
- 冠動脈疾患 (CAD) の予測のための非侵襲的動脈硬化と波反射マーカーを評価する.
- 増幅指数 (AIx) と増圧 (AP) とCADリスクとの関連性を評価する.
主な方法:
- 冠動脈血管撮影を受ける465人の症状のある男性の将来的な登録.
- アプラネーショントノメトリーと移転関数解析を用いた動脈硬化と波反射の非侵襲的定量化.
- 放射線動脈の波形から増圧 (AP) と増幅指数 (AIx) の計算.
主要な成果:
- より高いAIxは,単変数解析でCADリスクの増加と有意に関連していた (OR,4.06).
- この関連性は,伝統的なリスク要因とは独立して,多変量分析 (OR,6.91) で依然として有意であった.
- リスク関連は特に若い男性 (≤60歳) で強く,調整されていないORは8.25で,調整されたORは16.81でした.
結論:
- 非侵襲的に決定されたAIxとAPは,早発性冠動脈疾患の堅牢で独立したリスクマーカーです.
- これらの非侵襲的パラメータは,動脈硬化と波反射を反映し,心血管リスク評価に役立ちます.
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