C反応性タンパク質と高血圧を発症するリスク
Howard D Sesso1, Julie E Buring, Nader Rifai
1Department of Medicine, Center for Cardiovascular Disease Prevention and the Division of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass 02215-1204, USA. hsesso@hsph.harvard.edu
JAMA
|December 11, 2003
まとめ
炎症のマーカーであるC反応性タンパク質濃度の上昇は,女性において高血圧を発症するリスクの高さに関連しています. この発見は,高血圧が炎症的な起源を持っているという考えを裏付けている.
科学分野:
- 心血管の健康についてです.
- 炎症性疾患 炎症性疾患とは
- エピデミオロジー エピデミオロジー
背景:
- 高血圧は,一般的な心血管疾患です.
- 新興の証拠は,炎症と高血圧の間の潜在的な関連を示唆しています.
- システミック炎症マーカーとインシデント高血圧を直接結びつける臨床データは限られている.
研究 の 目的:
- 系統的炎症のマーカーであるC反応性タンパク質 (CRP) と高血圧の発生率との関連を調査する.
- 高濃度のCRPが,高血圧の将来的な発症を予測するかどうかを判断する.
主な方法:
- 45歳以上の女性医療従事者20,525人を対象とした前向きなコホート研究で,出血圧は正常であった.
- インシデント高血圧の追跡期間の中央値は7.8年であった.
- ベースラインの血CRP濃度と冠動脈リスク因子を測定した.
主要な成果:
- 高いベースラインのCRPレベルと高血圧を発症するリスクの増加 (P<.001) の間で,有意な線形傾向が観察されました.
- 伝統的な冠動脈リスク因子を調整した後でも,CRPの上昇は,インシデント高血圧のより大きなリスクと関連していた.
- この関連性は,低血圧と伝統的な危険因子のない患者を含む様々なサブグループで持続しました.
結論:
- 血のC反応性タンパク質レベルは,高血圧の将来の発達と有意に関連しています.
- これらの発見は,高血圧が部分的に炎症性疾患であるという仮説を支持する.
- CRPは高血圧リスクを予測する貴重なバイオマーカーとして役立つ可能性があります.
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