嗅覚球のグルメルーリの中央周回阻害

J L Aungst¹, P M Heyward, A C Puche

¹Department of Anatomy and Neurobiology, Program in Neuroscience, The University of Maryland School of Medicine, Room 222, 685 West Baltimore Street, Baltimore, Maryland 21201, USA.

Nature

|December 12, 2003

まとめ

短いアクソン細胞は,嗅覚球のグルメリルを接続し,新しい阻害ネットワークを形成します. この回路は,コントラストを増やし,神経応答を精錬することによって,匂いの信号処理を強化します.

科学分野:

神経科学は神経科学である.
センサリー処理センサリー処理
嗅覚系は嗅覚システムです.

背景:

センサリーシステムにおけるコントラスト強化には,センター・サウンドの抑制が不可欠です.
嗅覚球のグルメルーリとの相互作用はよく理解されていません.

研究の目的:

嗅覚球のグルメルーリとの機能的相互作用を調査する.
嗅覚処理における短いアクソン細胞の役割を明らかにする.

主な方法:

嗅覚球における電気生理学的記録.
細胞間結合の解剖学的な追跡.
シナプス生理学的研究.

主要な成果:

短い軸索細胞は,長い球間軸索を延長し,遠くにある球根を接続します.
これらの細胞は,抑制性ペリグロメルーラニューロンを刺激する.
これは,ミトラ細胞を阻害するオン・センター・オフ・サウンド回路を形成します.

結論:

嗅覚球に新しい,長距離の,球間抑制回路が存在する.
この回路は,既存の阻害経路とともに,時空の匂いの反応を高めます.

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