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Flow Cytometric Characterization of Murine B Cell Development
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Bリンパ球とTリンパ球の発達と維持には,抗アポプトティックMCL-1が必要である

Joseph T Opferman1, Anthony Letai, Caroline Beard

  • 1Howard Hughes Medical Institute, Dana Farber Cancer Institute, Department of Pathology and Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA.

Nature
|December 12, 2003
PubMed
まとめ

アンチアポプトシスタンパク質MCL-1はリンパ球の発達と生存に不可欠です. 欠乏するとB細胞とT細胞の成熟が停止し,成熟した細胞の急速な損失を引き起こし,MCL-1を強調します.

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