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A Platform of Anti-biofilm Assays Suited to the Exploration of Natural Compound Libraries
09:39

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Published on: December 27, 2016

Mycobacterium tuberculosisのプロテアゾームは,酸化窒素に対する耐性のために必要である

K Heran Darwin1, Sabine Ehrt, José-Carlos Gutierrez-Ramos

  • 1Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA.

Science (New York, N.Y.)
|December 13, 2003
PubMed
まとめ

Mycobacterium tuberculosis (Mtb) は,そのプロテアソームを使用して,反応性窒素中間体 (RNI) に対して防御します. この発見は,RNI耐性にとって不可欠なMtb遺伝子を特定することによって,抗結核薬のための新しい標的を明らかにします.

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