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関連する概念動画

Mismatch Repair01:36

Mismatch Repair

Overview
Fixing Double-strand Breaks02:04

Fixing Double-strand Breaks

The double-stranded structure of DNA has two major advantages. First, it serves as a safe repository of genetic information where one strand serves as the back-up in case the other strand is damaged. Second, the double-helical structure can be wrapped around proteins called histones to form nucleosomes, which can then be tightly wound to form chromosomes. This way, DNA chains up to 2 inches long can be contained within microscopic structures in a cell. A double-stranded break not only damages...
Protein Folding Quality Check in the RER01:29

Protein Folding Quality Check in the RER

ER is the primary site for the maturation and folding of soluble and transmembrane secretory proteins. The calnexin cycle is a specific chaperone system that folds and assesses the confirmation of N-glycosylated proteins before they can exit the ER lumen. The primary players of this quality check pipeline are the lectins, ER-resident chaperones, and a glucosyl transferase enzyme. In case the calnexin system in the lumen fails to salvage a misfolded protein, it is transported to the cytoplasm...
Mismatch Repair01:20

Mismatch Repair

Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
Fixing Double-strand Breaks02:04

Fixing Double-strand Breaks

The double-stranded structure of DNA has two major advantages. First, it serves as a safe repository of genetic information where one strand serves as the back-up in case the other strand is damaged. Second, the double-helical structure can be wrapped around proteins called histones to form nucleosomes, which can then be tightly wound to form chromosomes. This way, DNA chains up to 2 inches long can be contained within microscopic structures in a cell. A double-stranded break not only damages...
Errors in Taping01:18

Errors in Taping

Errors in taping arise from multiple factors that can significantly impact measurement accuracy in surveying. Misalignment of the tape, often due to human error, is one primary source. A skilled rear tapeman, using a telescope, can help correct alignment by guiding the head tapeman; however, human limitations still lead to small inaccuracies. These errors may include misplacement of pins or inaccurate tape readings due to common visual confusions, such as mistaking a six for a nine. Such...

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関連する実験動画

Updated: May 11, 2026

The Vermicelli and Capellini Handling Tests: Simple quantitative measures of dexterous forepaw function in rats and mice
09:37

The Vermicelli and Capellini Handling Tests: Simple quantitative measures of dexterous forepaw function in rats and mice

Published on: July 22, 2010

タンパク質の折り畳みと誤折り畳み

Christopher M Dobson1

  • 1University of Cambridge, Department of Chemistry, Lensfield Road, Cambridge CB2 1EW, UK. cmd44@cam.ac.uk

Nature
|December 20, 2003
PubMed
まとめ

タンパク質が特定の形状に折りたたまれることは,生物学的機能と細胞のターゲティングに不可欠です. 誤った折りたたまれたタンパク質は集積し,衰弱する病気につながる可能性があります.

科学分野:

  • バイオケミストリー バイオケミストリー
  • 分子生物学は分子生物学である.
  • 細胞生物学 細胞生物学

背景:

  • タンパク質の折り畳みは,細胞機能に不可欠な複雑な生体物理的プロセスです.
  • 細胞環境は,タンパク質の折り畳み経路に大きな影響を与えます.
  • 誤った折りたたまれたタンパク質の集積は,多くの病気に関与しています.

研究 の 目的:

  • 細胞環境内のタンパク質の折り畳みを支配する要因を解明する.
  • タンパク質の誤折りや結合のメカニズムを理解する.
  • タンパク質の折りたたみ欠陥と疾患の病原性との関係を調査する.

主な方法:

  • タンパク質の折り畳みダイナミクスの計算モデリング.
  • タンパク質-リガンドの相互作用を研究するためのインビトロアッセイ.
  • タンパク質の局所化と結合を視覚化するための細胞画像技術.

主要な成果:

  • タンパク質の折り畳みを決定する重要なアミノ酸配列のモチーフを特定しました.
  • 細胞の混雑が折りたたみ効率に与える影響を実証した.
  • 特定の誤折りたたまれたタンパク質の変異の結合傾向を特徴づけた.

さらに関連する動画

Errors as a Means of Reducing Impulsive Food Choice
07:07

Errors as a Means of Reducing Impulsive Food Choice

Published on: June 5, 2016

High-throughput, Microscale Protocol for the Analysis of Processing Parameters and Nutritional Qualities in Maize (Zea mays L.)
05:55

High-throughput, Microscale Protocol for the Analysis of Processing Parameters and Nutritional Qualities in Maize (Zea mays L.)

Published on: June 16, 2018

関連する実験動画

Last Updated: May 11, 2026

The Vermicelli and Capellini Handling Tests: Simple quantitative measures of dexterous forepaw function in rats and mice
09:37

The Vermicelli and Capellini Handling Tests: Simple quantitative measures of dexterous forepaw function in rats and mice

Published on: July 22, 2010

Errors as a Means of Reducing Impulsive Food Choice
07:07

Errors as a Means of Reducing Impulsive Food Choice

Published on: June 5, 2016

High-throughput, Microscale Protocol for the Analysis of Processing Parameters and Nutritional Qualities in Maize (Zea mays L.)
05:55

High-throughput, Microscale Protocol for the Analysis of Processing Parameters and Nutritional Qualities in Maize (Zea mays L.)

Published on: June 16, 2018

結論:

  • タンパク質の折り畳みは,内在的な配列特性と外在的な細胞因子の間の微妙なバランスです.
  • タンパク質品質管理の障害は,病原菌の蓄積につながる可能性があります.
  • タンパク質の折り畳みを理解することは,タンパク質の誤折り畳み疾患に対する治療戦略の開発に不可欠です.