運動は,内皮の原始細胞を増やし,ネオインティマの形成を阻害し,血管新生を促進します
Ulrich Laufs1, Nikos Werner, Andreas Link
1Medizinische Klinik und Poliklinik der Universität des Saarlandes, Innere Medizin III, Homburg, Germany. ulrich@laufs.com
Circulation
|December 24, 2003
まとめ
身体活動は,窒素酸化物 (NO) に依存する抗アポプトシスメカニズムを通じて,内皮原細胞 (EPC) を強化します. このEPCの増加は,心血管疾患に対する運動の利点を説明する可能性がある.
科学分野:
- 心血管科学の研究について
- 運動生理学 運動生理学
- 細胞生物学 細胞生物学
背景:
- 運動が心血管の健康,特に外周動脈および冠動脈疾患を改善するメカニズムは不明である.
- 骨髄から派生した内皮原生細胞 (EPC) は,血管修復,血管新生,動脈硬化症の緩和に関与しています.
研究 の 目的:
- 骨髄由来の内皮原生細胞 (EPCs) に対する身体活動の影響を調査する.
- 運動によるEPC変化における酸化窒素 (NO) とアポトーシスの役割を明らかにする.
- 運動が血管修復とネオインティマ形成に及ぼす機能的影響を評価する.
主な方法:
- ネズミはランニングホイールプロトコル (5.1+/-0.8 km/d) または静止状態で,EPCは光活性化細胞ソルター分析で定量化されました.
- 研究には,NO依存性を評価するためにN(G) -nitro-l-arginineメチルエステルで治療されたeNOS-/-マウスと野生型のマウスが含まれていました.
- 血管修復は,頸動脈損傷と皮下ディスク血管新生モデルを使用して評価されました. 中程度の運動訓練を受けた冠動脈疾患の患者 (n=19) のデータも分析した.
主要な成果:
- 運動は,外周血液,骨髄,およびマウスの臓由来単核細胞における循環中のEPCを有意に増加させた.
- 運動によるEPC増加は,eNOS-/-マウスおよびN(G) -nitro-l-arginineメチルエステルで治療されたマウスで弱まり,NO依存性を示しました.
- ランニングはネオインティマの形成を22+/-2%抑制し,ネオアニオゲネシスを41+/-16%増加させた.
- 冠動脈疾患の患者では,運動トレーニングにより循環中のEPCが増加し,EPCアポトーシスが減少しました.
結論:
- 身体活動は,EPCの生産と流通を促進します.
- 心血管の健康に対する運動の有益な効果は,EPCを含む部分的にNOに依存する抗アポプトシスメカニズムによって媒介される可能性があります.
- 研究結果は,身体活動の促進が,血管の機能と修復を改善する戦略である可能性があることを示唆しています.
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